KEGG pathway analysis of the upregulated genes (Supplementary Material 2) revealed involvement in the cell cycle, DNA replication, protein digestion and absorption, extracellular matrix (ECM)–receptor interaction, small cell lung cancer, amoebiasis, p53 signaling pathway, cancer pathway, IL-17 signaling pathway, and AGE-RAGE signaling pathway in diabetic complications13–16(Fig. 1D). This evidence concerns the gene RENBP and cancer.