CD8A and neoplasm: In turn, CD8 Tex cells in the LN-out highly expressed TGF-β1, IFN-γ, and ITGB1, which target FN1, EGFR, CTNNB1, COL1A1, and CFLAR in tumor cells, activating downstream pathways including ERK1 and ERK2 cascade (Fig. 5G).