Key findings of such studies include identification of the p-EMT program in malignant cells in vivo and its association with metastasis, discovery of germinal center B cells and divergent myeloid states in HPV+ TILs, and knowledge of the dominant contributing role of tumor-associated macrophages in the expression of PD-L1 and other immune checkpoint ligands1,5,6. This evidence concerns the gene CD274 and neoplasm.