HMGB2 in POSTN+ fibroblasts is predicted to bind to PLD2, LRP5, MYLK, and CD44 on tumor cells, regulating downstream genes, including BIRC5, CCNA2, CCNB1, CCNB2, CDC20, and MKI67, which are related to the cell cycle. The gene discussed is PLD2; the disease is neoplasm.