In turn, CD8 Tex cells in the LN-out highly expressed TGF-β1, IFN-γ, and ITGB1, which target FN1, EGFR, CTNNB1, COL1A1, and CFLAR in tumor cells, activating downstream pathways including ERK1 and ERK2 cascade (Fig. 5G). This evidence concerns the gene CFLAR and neoplasm.