Thus, collectively, these results demonstrate that ALDH2 activity deficiency, but not enhanced ADH1B activity, augments Aβ pathology in human brains, evidenced by increased amyloid plaque load and a higher Aβ40/42 ratio, indicating the ALDH2 rs671 G>A variant is not an independent risk factor for AD. Here, ALDH2 is linked to Alzheimer disease.