We verified that pT3-NrasG12V/PtenKO HCC model recapitulated the features of pT/CaggsNrasG12V-IRES-Luc NrasG12V/PtenKO (Supplementary Fig. 1c), confirming that the aggressivity of the distinct Nras-driven models was subsequent to the introduced Nras point mutations in hepatocytes. This evidence concerns the gene NRAS and hepatocellular carcinoma.