Altogether, these results suggest that cancer cell-intrinsic features shape several of the Nras-driven tumor characteristics, including the myeloid cell proinflammatory education identified in the CD45+ immune cells (Fig. 3f) and single-cell RNA-seq analyses (Fig. 4) of NrasG12D/PtenKO HCC. This evidence concerns the gene PTPRC and hepatocellular carcinoma.