CSF2 and hepatocellular carcinoma: Analysis of the polarization profile of NrasG12D/PtenKO-induced Ly6Clow cells showed an enrichment of the immunosuppressive markers CD39 and PD-L1, a feature comparable to recombinant GM-CSF exposure (Fig. 7b) and corroborating with the phenotype of myeloid cells present within NrasG12D/PtenKO HCC (Supplementary Fig. 3b).