Concomitantly, NrasG12D/PtenKO displayed an enrichment in several proinflammatory pathways with well-described HCC pro-tumorigenic features6 also characteristic of the TIME-SM human subtype, such as NF-κB, IL1R, IL6, and TNFR1 (Fig. 3f). The gene discussed is TNFRSF1A; the disease is hepatocellular carcinoma.