Of note, the BETi-mediated down-regulation of ICs observed in NKs was associated with a concomitant reduction of respective IC ligands in tumor cells (such as PD-L1, PD-L2, LSGAL9, HVEM), both NSCLC cell lines and patient-derived tumors (Suppl. This evidence concerns the gene CD274 and non-small cell lung carcinoma.