Similar to SLE patients13, the accumulation of mitochondrial mass was attributed to Rab4A-mediated Drp1 depletion in CD4+ T cells of B6/Rab4AQ72L (Fig. S4A) and B6.TC/Rab4AQ72L mice (Fig. S4B). This evidence concerns the gene CD4 and systemic lupus erythematosus.