In response to Rab4A-driven lupus pathogenesis, mTORC1 was consistently activated in CD3+, CD4+, and CD8+ T cells of 20-week-old B6.TC/Rab4AQ72L mice relative to B6/Rab4AQ72L controls (Fig. S5). The gene discussed is CD8A; the disease is systemic lupus erythematosus.