In fact, examining the gene sets affected by Hpa2-Nuc in both the ZR-75-1 and MDA-MB-231 cell models pointed to pathways that relate to the tumor microenvironment (Fig. 7), including increased levels of MHC-I, responsible for the presentation of tumor antigens to cells of the immune system and noticeable recruitment of NK cells to Hpa2-Nuc tumors (Fig. 7). Here, HPSE2 is linked to neoplasm.