HPSE2 and cancer: Furthermore, MDA-MB-231-Hpa2-Nuc cells were far more sensitive to conditions of anoikis (i.e., lack of cell attachment) [49], resulting in over 3-fold increase in cell death vs control (Vo) and Hpa2 cells, and exhibited decreased number and size of cancer stem-cells spheroids (Fig. 6F and Supplementary Fig. 6D).