In accordance with this, altered lymphoid follicle architecture has been reported in CXCR4 GOF Cxcr4+/1013 mice and in two histopathological reports of lymph nodes from WHIM patients, but the origin of these abnormalities is difficult to interpret in the context of WHIM-associated lymphopenia (Zuelzer, 1964; Mentzer et al, 1977; Balabanian et al, 2012). Here, CXCR4 is linked to lymphopenia.