In pathological contexts, CXCR4 is implicated in both cancer development and progression, as well as viral infections, particularly in the case of HIV-1, where CXCR4 serves as the coreceptor for CD4 on T cells during infection (Deng et al, 1996; Guo et al, 2016). This evidence concerns the gene CXCR4 and viral infectious disease.