In addition, immunoblotting of the samples with anti-pT269-S6K and anti-pT37/46-4EBP1 antibodies revealed that the phosphorylation of S6K and 4EBP1 is reduced in cells with p62-T269A compared to cells with p62-WT in SK-Mel-28-DYRK3 stable melanoma cell (Fig. S3, A and B). The gene discussed is DYRK3; the disease is melanoma.