SQSTM1 and neoplasm: To further investigate the effect of DYRK3-mediated p62 phosphorylation on in vivo tumorigenesis, several SK-Mel-28 cell lines stably expressing DYRK3-WT, p62-WT, p62-T269A, or p62-T269E, as well as mock-transfected control cells, were subcutaneously injected into nude mice, and tumor growth was monitored.