,15,16,17 CXCL9 and CXCL10 (CXCL9/10) signal through C-X-C motif chemokine receptor 3 (CXCR3) to promote the tumor infiltration of CXCR3+ effector T cells, including type 1 T helper (Th1) cells and CD8+ cytotoxic T lymphocytes.18 This evidence concerns the gene CXCL9 and neoplasm.