As an acute-phase negative protein, serum albumin can serve as a prognostic biomarker in patients with sepsis.[9] Some studies have demonstrated that albumin levels <28 g/L are an independent risk factor for sepsis mortality, and low albumin levels increase the sepsis mortality rate.[10] Our study also revealed that sepsis patients with albumin ≤23.11 g/L within 24 hours of admission had a significantly increased 28-day mortality rate, supporting previous conclusions. The gene discussed is ALB; the disease is Sepsis.