PTK2 and neoplasm: Moreover, FAK/PTK2 is overexpressed and activated in many types of advanced solid cancers, including colorectal,[11] ovarian,[12] esophageal,[13] and hepatocellular[14] carcinomas, and is associated with poor overall survival.[7,15] FAK/PTK2 reportedly plays an important role in tumor adhesion, diffusion, motility, invasion, metastasis, survival, angiogenesis, epithelial to mesenchymal transformation, cancer stem cells, and the tumor microenvironment (TME).[16–18]