PTK2 and neoplasm: Generally, more new antigens may be formed in a tumor with more somatic mutations, and TMB provides a useful tumor neoantigen load.[48] In contrast, MSI is defined as a robust mutant phenotype caused by DNA mismatch repair defects and is a potential predictive marker of immunotherapy.[49] FAK/PTK2 is correlated negatively with TMB and MSI in COAD, but positively with these 2 biomarkers in STAD.