NFKB1 and aneurysm: Macrophage specific deletion of the prostaglandin E receptor subtype 2 (EP2) (Ptger2), an upstream signaling receptor for NF-κB activation, significantly suppresses the development of IA in mice, indicating that prostaglandin E2-EP2-NF-κB signaling in macrophages plays a crucial role in IA development.[52] SDF-1 is associated with inflammatory cell migration and proliferation in the walls of mice aneurysms, and may have a role in the rupture of IA.[53] Second, we did not have control over data collection as we used pure public data and therefore the data quality is not certain.