APLP1 and early-onset autosomal dominant Alzheimer disease: Among the core genes, Previous studies have shown that p53-dependent induction of APLP1 is involved in neural cell death, and which may exacerbate neuronal cell loss in some acute or chronic neurodegenerative disorders.[34] At the same time, APLP1 plays an important role in the chronic inflammatory response of neuronal cells[35] and the severity of some diseases such as Alzheimer’s disease.[36] The SLC39A12 gene encodes the zinc transporter ZIP12, which is expressed in many tissues and is abundant in the vertebrate nervous system.