Recently, GATA2 mutation have been involved in some complex clinical syndromes overlapping features which include familial myelodysplastic syndrome (MDS), AML, MonoMAC syndrome characterized by peripheral monocytopenia, Emberger syndrome (primary lymphedema with MDS), and B- and NIC-cell lymphocytopenia, increased susceptibility to mycobacterium infection and a predisposition to acute myeloid leukaemia and myelodysplastic syndrome. Here, GATA2 is linked to myelodysplastic syndrome.