A recent study by Celton et al (2014) using RNA sequencing reported a reduction in GATA2 protein expression in normal karyotype AML due to aberrant DNA methylation.[23] Along with previous observation GATA2 being one of the most deferentially hypomethylated locus in DNMT3a knockout mice.[24] These findings implicated the epigenetic regulation of GATA2 is likely, though not sufficient by itself, included in the epigenetic modulation during leukemogenesis.[25]. Here, GATA2 is linked to acute myeloid leukemia.