CD4 and neoplasm: Central memory CD4 + T cells maintain immune memory and play an immunoprotective role during tumor metastasis.[21,22] Effector memory CD4+ T cells express adhesion molecules and chemokine receptors that perform rapid functions.[23,24] Studies have reported that patients with high memory T-cell activation have shorter OS, whereas those with high memory T-cell quiescence have longer OS.[25] However, a higher proportion of Tregs was found in the low-risk score group than in the high-risk score group.