In cancer, tumor-associated macrophages can suppress anti-tumor immunity, promote tumor progression, and negatively correlate with patient prognosis.[19] T cells CD4 + memory activated, plasma cells were associated with longer OS.[20] Our results of reduced T cell CD4 + memory activation and plasma cell abundance and poor prognosis in the high-risk group, as opposed to macrophages, are consistent with previous findings. Here, CD4 is linked to cancer.