This is a form of cell death induced by the abnormal accumulation of high intracellular disulfides in SLC7A11 under glucose starvation conditions, which is distinct from apoptosis and demyelinating anemia.[8] Disulfide polymerization in mitochondria can control cancer cell fate.[16] However, the relationship between HNSCC and disulfidptosis remains unclear. The gene discussed is SLC7A11; the disease is cancer.