CD177 and infection: Given the pronounced phenotype observed in murine infection models, our study raises the question how CD177-deficient individuals [up to 10% of Caucasians (54, 79, 82)] manage to contain microbial intruders in the absence of neutrophilic CD177 expression, especially in settings where neutrophils may need to (trans)migrate across endothelial or epithelial barriers to reach the culprit pathogen.