CD177 up-regulation was more pronounced in LPS-treated than N-formylmethionine-leucyl-phenylalanine (fMLP)–, zymosan-, or phorbol 12-myristate 13-acetate–treated neutrophils, indicating TLR4-mediated signaling as a putative culprit event in infection-associated peripheral priming (fig. This evidence concerns the gene TLR4 and infection.