CD177 and infection: While our data including the observed dynamics of up-regulation of CD177 in acute infection models imply transcriptional plasticity as a crucial mechanism of CD177 up-regulation, previous work has highlighted complex epigenetic regulatory mechanisms that govern CD177 expression, including activator protein 1–induced promoter activation as well as (de)methylation-induced activation or silencing of the CD177 locus (79, 80).