A group of lysozyme genes (like lys-4, lys-6 and ilys-5), C-type lectin genes (like ugt-30, ugt-6, ugt-64 and ugt-53) and UDP-Glucuronosyl transferase genes (like ugt-30, ugt-6, ugt-64 and ugt-53) were also commonly down-regulated by HIF-1 high-activity and P. aeruginosa PA14 infection (S17 Table). The gene discussed is LYZ; the disease is infection.