Compared to the mock group, HEV3 infection without tacrolimus treatment resulted in a significant increase of several pro-inflammatory mediators, including TNF-α, IL-2, IL-6, sICAM-1, CCL-3, CCL-4, G-CSF, and GM-CSF in human Sertoli cells (Figure 4(A and B)). The gene discussed is CSF2; the disease is infection.