This study presents the first report and validates the regulatory effect of lncRNA FOXD1‐AS1 in enhancing the PD‐L1 expression by sequestering miR‐615‐3p as a ceRNA and inhibiting CD8+ T‐cell response, indicating that lncRNA FOXD1‐AS1 might play import role in immune escape in HCC in vitro. This evidence concerns the gene FOXD1 and hepatocellular carcinoma.