LDLR is negativelyregulated by PCSK9, and its reduction in the liver could lead to increasedplasma LDL cholesterol, leading, in turn, to hypercholesterolemia.25 Therefore, the regulation of these proteinsby inducing LDLR expression with PCSK9 inhibition could potentiallycontrol hepatic cholesterol uptake. This evidence concerns the gene PCSK9 and Hypercholesterolemia.