LDLR and familial hypercholesterolemia: LDLR is negativelyregulated by PCSK9, and its reduction in the liver could lead to increasedplasma LDL cholesterol, leading, in turn, to hypercholesterolemia.25 Therefore, the regulation of these proteinsby inducing LDLR expression with PCSK9 inhibition could potentiallycontrol hepatic cholesterol uptake.