ECM1 and cancer: Wang et al. (2023)demonstrated that the extracellular matrix protein 1 (ECM1), elevatedlevels of which have been identified in malignant epithelial tumors,could regulate cholesterol biosynthesis and consequently trigger angiogenesisand cancer malignancy.21 Notably, the herbpair of Citri Reticulatae Pericarpium and Reynoutria japonica Houtt.