Notably, we demonstrated this disconnection under certain pathologic conditions on the expression of the SQLE gene and protein (Jun et al., 2021); SQLE degradation caused by accumulated cholesterol over a certain threshold accelerates CRC progression and metastasis via activating the β‐catenin oncogenic pathway by inhibiting the p53 anti‐tumor suppressor path and GSK3β activity. The gene discussed is TP53; the disease is colorectal carcinoma.