Notably, we demonstrated this disconnection under certain pathologic conditions on the expression of the SQLE gene and protein (Jun et al., 2021); SQLE degradation caused by accumulated cholesterol over a certain threshold accelerates CRC progression and metastasis via activating the β‐catenin oncogenic pathway by inhibiting the p53 anti‐tumor suppressor path and GSK3β activity. This evidence concerns the gene GSK3B and colorectal carcinoma.