TP53 and colorectal carcinoma: Furthermore, we investigated the effectiveness of SQLE and the critical players in the β‐catenin pathway (p53 wild‐type: p53WT, p53 mutant: p53MT, and the GSK3β activity inhibition, as measured by the phosphorylation at serine 9 of GSK3β: GSK3βpS9) as prognostic and diagnostic biomarkers in high‐risk CRC patients.