2014; Shi and Fu 2019). In this study, we found that DG treatment increased Nrf2 expression and its downstream antioxidative enzymes NQO1 and HO-1 while inhibiting Keap1 expression in MGN rats. These findings are supported by previous studies demonstrating that DG treatment induces the expression of NQO1 and HO-1 through activation of the Nrf2/Keap1 pathway (Wang R et al. 2015; Bloomfield et al. 2017). Here, KEAP1 is linked to idiopathic membranous glomerulonephritis.