2016). Podocyte foot processes surround the GBM, forming slit diaphragms between adjacent foot processes, and slit diaphragm dysfunction results in proteinuria (Nanri et al. 2009). As key functional molecules in the podocyte slit diaphragm, nephrin is located at the outer leaflet of plasma membranes of podocyte slit diaphragm, while podocin interacts with nephrin (Tryggvason et al. 2006). Previous studies have shown that lower nephrin and podocin expression in MGN rats compared with NCs (Lu et al. 2014). Here, NPHS2 is linked to idiopathic membranous glomerulonephritis.