IL2 and type 1 diabetes mellitus: Importantly, the inclusion of CISC in the human EngTregs allows for production of dual-edited GNTI-122 cells with high purity and facilitates persistence of the adoptively transferred GNTI-122 cells in vivo (18, 19), providing cell-intrinsic IL-2 signaling designed to overcome limited IL-2 availability within the T1D pancreatic environment (6–13).