In addition, we found a significant increase in tubular injury–related mRNA levels, specifically Havcr1 and Serpina3c in the IR group; although there was a trend of lower mRNA levels of these tubular injury biomarkers in the IR + Dapa group, they remained higher compared with the Sham group, indicating a persistent degree of tubular injury in both AKI groups (Figure 1, K and L). Here, HAVCR1 is linked to acute kidney injury.