PAX8 and Balkan nephropathy: To address this question, we selectively deleted Cpt1a in renal tubules using the inducible Pax8-rTTA;tetO-Cre mice (13) and either aged the mice for 2 years or subjected them to the unilateral ureteral obstruction (UUO) or aristolochic acid nephropathy (AAN) chronic kidney injury models.