The level of NFE2L2 has been directly correlated with ferroptosis sensitivity, as increased expression of NFE2L2 prevents ferroptosis, whereas decreased NFE2L2 enhances the sensitivity of cancer cells to pro‐ferroptosis agents.NFE2L2 can enhance the ability of the Xc‐ system to protect cells from ferroptosis, and cystine uptake mediated by the Xc‐ system is essential for the synthesis of GSH.78 The gene discussed is NFE2L2; the disease is cancer.