KEGG enrichment analysis showed PD‐L1 expression and PD‐1 checkpoint pathway in cancer was another pathway enriched in all of the four cell lines transfected with SESN1 siRNA #1 and siRNA #2 (Figure 6B), and NB was a typical “cold tumor” with an impressive immune microenvironment. The gene discussed is SESN1; the disease is neuroblastoma.