The expressions of PPARG, VCAM1, KDR1, and SOD1 were detected in the tumor tissues of TNBC mice, and the results showed that SYF can significantly upregulate the expression of PPARG while downregulating the expression levels of VCAM1, KDR1, and SOD1, which is consistent with the network pharmacology and molecular docking results. The gene discussed is VCAM1; the disease is neoplasm.