However, NF-κB activation in astrocytes in the pre-symptomatic phase of ALS triggered a beneficial microglia activation (indicated by decreasing disease markers, delaying loss of MNs and denervation, and prolonging the pre-symptomatic phase) and slowed disease progression in G93A*SOD1 mice [44]. This evidence concerns the gene NFKB1 and amyotrophic lateral sclerosis.