ICPi: immune checkpoint inhibitors; AKI: acute kidney injury; PPIs: proton pump inhibitors; RAASi: renin angiotensin aldosterone system inhibitors; C3GN: complement 3 glomerulonephritis; CPI: checkpoint inhibitors; AIN: acute interstitial nephritis; PD1i: programmed death 1 inhibitor; PD-L1: programmed death-ligand 1; TIN: tubulointerstitial nephritis; MN: membranous nephropathy; T-VEC: talimogene laherparepvec; IRAEs: immune-related adverse events; CRS: cytokine release syndrome; HLH: hemophagocytic lymphohistiocytosis; MAS: macrophage activation syndrome; CAR-T: chimeric antigen receptor. The gene discussed is CD274; the disease is interstitial nephritis.