Although there is currently no specific mechanism-related study on the regulation of ERCC4 in the development of IBD-related CAC through p53, based on its role as a member of the XP family and its biological functions in DSB repair pathways and telomere maintenance pathways, it is hypothesized that ERCC4 may be a potential regulatory factor in the occurrence and development of ulcerative colitis and related cancers. This evidence concerns the gene TP53 and cancer.