Ten most closely linked genes (HSPA1B, HSPB1, HSPA1A, DNAJB1, HSPB8, ANXA2, ANXA1, SOX9, YAP1 and AHNAK) in the network data were extracted and identified as the hub genes of AD using the huba algorithm of cytoscape software (Figure 6D). Here, HSPB8 is linked to Alzheimer disease.