As shown in Figure 7 among these 10 hub genes, HSPA1B and HSPB1 have weak diagnostic efficacy for AD (AUC < 0.6), DNAJB1, ANXA2 and AHNAK have some diagnostic efficacy for AD (0.6 < AUC < 0.75), while SOX9, HSPA1A, ANXA1, HSPB8 and YAP1 have significant diagnostic efficacy for AD (AUC > 0.75). This evidence concerns the gene ANXA2 and Alzheimer disease.