ANXA2 and Alzheimer disease: We found that ANXA2 did not exhibit a direct association with AD, but it has been shown that ANXA2 develops calcium-regulated membrane-cytoskeletal junctions that exhibit interactions with tau proteins in the context of Ca2+ segregation or elimination of differential capture of tau proteins by knockdown of ANXA2 (Gauthier-Kemper et al., 2011).