Given that CD54 (also known as intercellular adhesion molecule-1, ICAM-1) is upregulated by inflammatory stimuli on airway epithelial cells (AECs) in asthma (Inoue et al.2020), a cyclic peptide (amino acid sequence: CSERSMNFC) ligand that efficiently binds to the CD54 receptor was chosen to construct AEC-specific siRNA-Pep-LNPs against thymic stromal lymphopoietin (TSLP) (Zhang et al.2022). This evidence concerns the gene TSLP and asthma.