For example, HA-decorated LNPs loaded with polo-like kinase 1 (PLK1) siRNA significantly reduced PLK1 mRNA levels by more than 80% in CD44 receptor-expressing glioblastoma multiforme (GBM) cells, which dramatically prolonged the survival time of treated mice in a human GBM U87MG orthotopic xenograft model (Cohen et al.2015). This evidence concerns the gene PLK1 and glioblastoma.