SPACA1 and Globozoospermia: Recently, proteins that, when mutated in mice, cause globozoospermia have been discovered, including DPY19L2, FAM209, FAM71F1, FAM71F2, GBA2, GOPC, PDCL2, PICK1, SPACA1, SSMEM1, and ZPBP1 (4–13).