Another colon cancer metastasis mouse model, AKPT, showed tumor regression after inhibition of TGF-β and PD-1/PD-L1.19 Enhanced Notch 1 activation and neutrophil infiltration differentiates the KPN model used here from other CRC models, including AKPT, and these factors may influence the therapeutic response. The gene discussed is NOTCH1; the disease is colonic neoplasm.