Moreover, overexpression of lncRNA TUG1, a natural anti-tumor agent, is discovered in DOX-resistant OS cells, while downregulation of TUG1 by polydatincan promotes DOX-induced apoptosis in vitro and inhibits tumor growth in the DOX-resistant model in vivo by suppressing the AKT signaling pathway (Zhou Q. et al., 2020). The gene discussed is AKT1; the disease is neoplasm.