At the same time, immunosuppression can universally repress the activity of UDP-galactose 4′-epimerase (Lee et al., 2014), while deficiency of each one of the three galactose-metabolism-related enzymes can lead to galactosemias, such as Escherichia coli sepsis (Novelli and Reichardt, 2000). This evidence concerns the gene GALE and classic galactosemia.