Anti-SSA/Ro and anti-SSB/La antibodies were positive in 41.4%, (95% CI 37.5%–45.3%) and 20.1%, (95% CI 17.4%–22.9%) of 1,039 (77.4%) and 1,018 (75.6%) SLE patients with data available, respectively. This evidence concerns the gene SSB and systemic lupus erythematosus.