It was reported that KLF15 negatively regulated cardiac fibrosis in mice with type 2 diabetes, and the cardio-protective effects of Stromal Cell-Derived Factor-1β (SDF-1β) are mediated by binding to the CXCR7 receptor and the p38β MAPK-mediated upregulation of KLF15 (71). Here, CXCL12 is linked to type 2 diabetes mellitus.