KLF15 and familial dilated cardiomyopathy: For example, KLF13, localized on chromosome 15q13.3, is a novel gene that increases the risk of cardiomyopathy (DCM), whereas KLF15 can prevent diabetic cardiomyopathy-induced cardiac dysfunction and myocardial fibrosis as well as hypertrophic cardiomyopathy (HCM) by repressing pro-hypertrophic transcription factors to attenuate LVH.