IL6 and central nervous system cancer: The same glioma cells are known to increase oxidative stress and stimulate the release of immunosuppressive molecules such as interleukin-6 (IL-6), IL-10 and tumor growth factor beta (TGF-β), which in turn reprogram the immune components of TME such as microglia to a pro-tumorigenic phenotype (Alghamri et al., 2021).