Concurrently, mHTT enhanced and further increased iron homeostatic factors (such as ferritin, TRF, IRP1, and TFR) in the striatum and cortex of HD transgenic mice's brains, indicating that mHTT may cause an excess of iron in HD by increasing IRP1 (Niu et al., 2018). The gene discussed is ACO1; the disease is Huntington disease.