Circ_HECTD1 deficiency offers a novel preclinical basis for cerebral ischemia injury and cerebral infarction via the circ_HECTD1/miR-27a-3p/FSTL1 axis and circ_HECTD1/miR-133b/TRAF3 axis (94, 95). This evidence concerns the gene HECTD1 and Cerebral ischemia.