GATA4 and Myocardial fibrosis: Additionally, it was verified that circ-sh3rf3 inhibited fibroblast-to-myofibroblast differentiation and consequently alleviated myocardial fibrosis by directly enhancing GATA-4 ubiquitination degradation via the E3 ubiquitin–protein ligase sh3rf3 and then abolishing GATA-4 inhibition of miR-29a expression (71).