In addition, the E3 ubiquitin ligase Nrdp1, which positively regulates the two core lncRNAs, NONRATT054243 and NONRATT057160, was also revealed to mitigate Ang II-induced cardiac hypertrophy by reducing downstream PIK3R3 expression and AKT phosphorylation (59). The gene discussed is MUL1; the disease is cardiac hypertrophy.