Moreover, five notable crosstalk pathways, circ-UBR4/miR-637/FOXO4, circ-UBR4/miR-107/ROCK1, circ-UBR4/miR-491-5p/NRP2, circ-UBR4/miR-185-5p/FRS2 and circ-CHFR/miR-214-3p/PAPPA axis, regulate VSMC migration and growth to improve atherosclerosis (75, 77–80). The gene discussed is PAPPA; the disease is atherosclerosis.