UCHL1 and ischemic stroke: Notably, in mouse ischemic stroke models (middle cerebral artery occlusion) in vivo, miR-181b expression is downregulated in response to ischemic exposure, thus ameliorating poststroke neurovascular injury by increasing ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) and HSPA5 expression (93).