Notably, circDLGAP4, lncRNA-Nespas, and SNHG15 can exert neuroprotective effects to alleviate ischemic stroke by decreasing the expression of the E3 ubiquitin ligase HECTD1 or inhibiting the ubiquitination of TAK1/TRAF2 (89, 92, 101). The gene discussed is MUL1; the disease is ischemic stroke.