HECTD1 and ischemic stroke: Additionally, circDLGAP4 expression was significantly downregulated in both stroke mouse models and plasma from ischemic stroke patients, but overexpression of circDLGAP4 sponged miR-143 and reduced E3 ubiquitin ligase HECTD1 expression, thereby ameliorating poststroke neurovascular injury and reducing infarct size (89).