PLPP3 and obesity due to melanocortin 4 receptor deficiency: Moreover, circSCMH1 promotes translocation of obesity-associated protein into the endothelial cell nucleus via ubiquitination and subsequently facilitates m6A demethylation of Plpp3 mRNA and upregulates Plpp3 expression, thereby enhancing vascular repair after stroke in mice in vivo and in vitro (91).