Furthermore, miR-454 exerts anti-apoptosis effects and improves HF via the miR-454/NEDD4-2/TrkA/cAMP axis (67), while miR-129-5p provides potential therapeutic benefits in CHF via modulation of the miR-129-5p/Smurf1/PTEN axis (68). This evidence concerns the gene SMURF1 and hydrops fetalis.