Additionally, inhibition of miR-181b, lncRNA-Fendrr, lncRNA MIAT and lncRNA SNHG3 was determined to play neuroprotective roles in treating cerebral I/R injury and ischemic stroke by promoting UCHL1/HERC2 expression or accelerating REDD1/HDAC3 ubiquitination degradation (93, 96, 98, 100). This evidence concerns the gene UCHL1 and ischemic stroke.