INS and type 1 diabetes mellitus: Conformational insulin epitopes in AKS-107 relevant to anti-insulin BCR binding were confirmed via ELISA in which AKS-107 bound the insulin-specific mAb, 125mAb, derived from a T1D pathogenic insulin-specific BCR and a second anti-insulin mAb, 123mAb (32, 42) (Figure 2A).