Hyperactivity of cGAS-STING pathway may lead to sustained immune response and result in autoimmune diseases, such as systemic lupus erythematosus (56), Aicardi-Goutières syndrome (29), STING-associated vasculopathy with onset in infancy (57), rheumatoid arthritis (58) and psoriasis (59). The gene discussed is STING1; the disease is systemic lupus erythematosus.