showed that the albumin/vaccine nanocomplexes containing CpG and Adpgk neoantigen showed a 14.1- and 13.6-fold higher frequency of antigen-specific CD8+ T cells compared to CpG + Adpgk and IFA(CpG + Adpgk) controls, and only albumin/vaccine nanocomplexes generated long-term survival in a MC38 tumor model, with 2 out of 16 mice surviving more than 30 d. This evidence concerns the gene CD8A and neoplasm.