In a phase I/Ib glioblastoma study, neoantigen vaccines containing synthetic long peptides mixed with poly-ICLC (polyinosinic and polycytidylic acid, stabilized with poly-L-lysine and carboxymethylcellulose) generated circulating neoantigen-specific CD4+ and CD8+ T cells and increased tumor-infiltrating T cells in patients not receiving dexamethasone [21]. This evidence concerns the gene CD8A and neoplasm.