A previous study reported that the PGE2/IL1 cytokine network mediates the interaction between TA-MSC and colon cancer cells, in which PGE2 and cytokines derived from cancer-educated MSC enhance IL1, IL6, and IL8 production in cancer cells, which in turn enriches the cancer stem cell population (43). This evidence concerns the gene IL1A and malignant colon neoplasm.