IL8 from TEC was reported to play a mediating role in prostate cancer progression (76); meanwhile, CXCR7, CXCR4, and VEGF are angiocrine factors TEC stimulate angiogenesis and enhance survival of TEC in an autocrine manner (35, 77), thus supporting tumor progression and metastasis (78). This evidence concerns the gene CXCR4 and neoplasm.