A previous study reported that the PGE2/IL1 cytokine network mediates the interaction between TA-MSC and colon cancer cells, in which PGE2 and cytokines derived from cancer-educated MSC enhance IL1, IL6, and IL8 production in cancer cells, which in turn enriches the cancer stem cell population (43). This evidence concerns the gene CXCL8 and colonic neoplasm.