Consistent with the upregulation of PGE2 in MpEV-ATMSC, non-aggressive BCC treated with MpEV-ATMSC-CM showed the upregulation of IL1α, IL6, and IL8 in response to the stimulation signal from PGE2 in comparison to those treated with ATMSC-CM or nEV-ATMSC-CM (Figure 3E). Here, IL6 is linked to skin basal cell carcinoma.