WNK2 and neoplasm: Among these flavonoids, apigenin has been studied for its anti-tumor properties against various cancer cells, that has been found to 1) inhibit the growth and proliferation of tumor cells along with modulation of signaling pathways including protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) (7–9), 2) induce apoptosis or programmed cell death (10), and 3) inhibit angiogenesis (11, 12), receptively.