Regarding modulations of MMPs and angiogenesis as the important molecular targets for the anti-metastatic action of apigenin, MMP2 in melanoma cells and MMP9 in melanoma and ovarian cancer cells, and vascular cell adhesion protein 1 (VCAM-1) in B16-BL6 melanoma cell were regulated. This evidence concerns the gene MMP2 and ovarian carcinoma.