Single-factor analysis revealed statistically significant differences in age, menopausal status, body mass index, body surface area, duration of chemotherapy infusion, daily water intake after chemotherapy, presence of a caregiver, hypertension, diabetes, tumor node metastasis stage, cumulative chemotherapy dose, vitamin D deficiency, abnormal alanine transaminase levels, abnormal aspartate transaminase levels, glucose abnormalities, pre-chemotherapy anemia, physical activity level, anxiety, depression, social support, and sleep quality (all P<0.05) between the patients with and without CIPN. This evidence concerns the gene GPT and major depressive disorder.