Multivariate logistic regression analysis revealed that age 45–59 years (OR=5.119) and ≥60 years (OR=9.366), history of hypertension (OR=3.475), cumulative dose of chemotherapy drugs >400 mg (OR=4.842), vitamin D deficiency (OR=6.214), alanine transaminase abnormality (OR=3.154), pre-chemotherapy anemia (OR=2.770), chemotherapy drug infusion duration >30 min (OR=3.673), body mass index ≥24 kg/m2 (OR=8.139), mild depression (OR=4.546), and severe depression (OR=4.455) were risk factors for CIPN in patients with breast cancer. Here, GPT is linked to major depressive disorder.