reported that, through the Notch signaling pathway, APS significantly promoted the production of cytokines such as IL-6 and TNF-α; increased the iNOS levels and polarization rate of M1/M2 macrophages; activated M1 macrophages; and inhibited M2 macrophages, thereby enhancing the killing and phagocytosis of tumor 4T1 cells and the inhibition of tumor growth and metastasis (144). This evidence concerns the gene TNF and neoplasm.