What’s more, study has shown that NRF2 negatively regulates the expression of focal adhesion protein FOCAD and attenuates its effect on enhancing the sensitivity of NSCLC cells to cysteine deprivation induced ferroptosis, while NRF2 inhibitor Brusatol enhances the therapeutic effect of FOCAD on NSCLC cells (34). The gene discussed is FOCAD; the disease is non-small cell lung carcinoma.