Recently, academia unearthed that 2-methoxy-6-acetyl-7-methyljuglone can trigger ferroptosis by targeting NAD(P)H quinone oxidoreductase 1 (NQO1) in drug-resistant NSCLC cells, opening the door to a new NQO1-mediated treatment modality to battle resistance (67). Here, NQO1 is linked to non-small cell lung carcinoma.